Introduction #
SeqSMART is designed to operate seamlessly across modern web browsers and institutional environments.
While there are no strict limitations on operating systems or hardware, optimal performance depends on browser version, connection speed, and server specifications (for local deployments).
This article outlines the general system requirements and supported environments to ensure the best SeqSMART experience.
1. General Overview #
SeqSMART is a web-based platform optimized for both cloud-hosted and local (on-premise) installations.
All core operations — case management, variant analysis, ACMG evaluation, and reporting — are performed via the web interface, with computation handled by the backend servers.
Users do not need to install any additional software or plugins to access SeqSMART.
A modern browser and a stable internet connection (or intranet access for local setups) are sufficient.
2. Supported Operating Systems #
SeqSMART is compatible with all major desktop operating systems:
- Windows: 10, 11, or later
- macOS: 11 (Big Sur) or later
- Linux: Ubuntu 20.04 or later (recommended for institutional environments)
Note: SeqSMART is optimized for desktop use. While the interface is responsive, certain advanced modules (e.g., ACMG criteria view or 3D protein visualization) are best experienced on larger screens.
3. Supported Browsers #
SeqSMART supports all major, standards-compliant browsers.
For best performance and full compatibility, always use the latest stable version of your browser.
| Browser | Minimum Supported Version | Recommended Version |
| Google Chrome | 100+ | Latest stable version |
| Mozilla Firefox | 95+ | Latest stable version |
| Microsoft Edge | 100+ | Latest stable version |
| Safari (macOS) | 15+ | Latest stable version |
Notes:
- Browser auto-update features are recommended to ensure compatibility with the latest security and visualization features.
- Internet Explorer is not supported.
- Some institutional browsers with restrictive configurations (e.g., disabled JavaScript or local cache restrictions) may limit functionality; please whitelist SeqSMART in such cases.
4. Network Requirements #
SeqSMART requires a stable and secure connection to its backend servers.
The exact bandwidth depends on case size and institutional infrastructure, but general recommendations are as follows:
- Minimum bandwidth: 5 Mbps (download) / 2 Mbps (upload)
- Recommended bandwidth: 20 Mbps or higher for smooth data loading and visualization
- Latency: <100 ms recommended
Tip: For laboratories using SeqSMART via VPN or local network, ensure consistent network access to the designated SeqSMART server IPs or domains.
5. Local and Hybrid Deployments #
Institutions hosting SeqSMART locally or in hybrid mode can configure hardware resources according to their data volume and analysis frequency.
Minimum server requirements:
- Processor: 16-core CPU (Intel Xeon / AMD EPYC or equivalent)
- Memory: 128 GB RAM or higher (depending on concurrent users)
- Storage:
- Primary SSD storage: ≥ 16 × 2 TB (RAID configured) for MongoDB and analysis data
- Secondary HDD storage for backups and archival
- Primary SSD storage: ≥ 16 × 2 TB (RAID configured) for MongoDB and analysis data
- Operating system: Ubuntu Server 22.04 LTS (recommended)
- Database: MongoDB 6.0+
- Network interface: 10 Gbps LAN connection for institutional use
These specifications ensure high-throughput analysis performance and stable multi-user access.
6. Client-Side Performance Tips #
For the best experience when working with large variant datasets or complex 3D visualizations:
- Close unused browser tabs or background-heavy applications.
- Enable hardware acceleration in your browser settings.
- Allow JavaScript and local caching for seqsmart.io or your institutional SeqSMART domain.
- Use a high-resolution display (Full HD or higher) for optimal data visualization.
7. Security and Access #
SeqSMART enforces modern web security standards across all supported browsers and servers:
- TLS 1.3 encryption for all data transfers
- Secure cookie handling and CSRF protection
- Role-based authentication and access logging
- Support for institutional single sign-on (SSO) configurations
Institutions can further restrict access using internal firewalls, IP whitelisting, or VPN tunnels, depending on their compliance policies.
8. Mobile and Tablet Access #
Due to the large amount of data displayed for each variant and case, SeqSMART’s analytical interface is not optimized for mobile or small tablet screens.
Certain visual components — such as variant tables, ACMG evidence layers, and 3D protein structures — require wider layouts to display information accurately.
For the best user experience and full access to all analytical features, it is strongly recommended to use SeqSMART on a desktop or laptop system with a large, high-resolution display.
SeqSMART is engineered for maximum compatibility and flexibility.
It runs securely in any modern browser, integrates smoothly into institutional IT environments, and scales efficiently from small labs to enterprise-level installations.
SeqSMART Environment Principle:
Accessible anywhere, optimized for professionals.