Introduction #
SeqSMART is built for professional genomic environments where collaboration, traceability, and data security are essential.
To ensure smooth teamwork and data governance, the platform employs a role-based access model that defines user permissions and workflow responsibilities.
While SeqSMART provides a standard role model suitable for most laboratories, it also offers complete flexibility — allowing institutions to redefine roles, access levels, and workflow steps to match their internal processes.
1. Role-Based Access Model #
SeqSMART uses a Role-Based Access Control (RBAC) framework, meaning that every user’s actions within the system are determined by their assigned role.
This model ensures that sensitive data remains secure and that every activity in the system is traceable.
Core Principles #
- Each user role defines specific privileges (create, review, approve, manage, or integrate).
- All operations are logged for audit and accountability.
- Institutions maintain full control over how roles and permissions are structured.
2. Standard Role Model #
SeqSMART provides a recommended role configuration that matches the workflow of most diagnostic and research laboratories.
This model includes three primary roles: Administrator, Analyst, and Checker (Reviewer).
2.1 Administrator #
Purpose: Oversee the entire platform and manage institutional settings.
Key permissions:
- Create, edit, or deactivate user accounts.
- Assign or modify user roles and permissions.
- Manage institutional parameters (report templates, naming rules, custom filters, etc.).
- Configure storage, backup, and data retention policies.
- Access audit logs and system usage analytics.
Typical users:
Laboratory directors, lead bioinformaticians, or IT managers.
2.2 Analyst #
Purpose: Perform variant analysis and prepare case results for review.
Key permissions:
- Create and manage cases.
- Upload variant and phenotype data.
- Review automated ACMG classifications.
- Modify evidence, add literature, or adjust classification when required.
- Prepare the report for validation by the checker.
Typical users:
Clinical geneticists, molecular biologists, or bioinformatics experts responsible for variant interpretation.
2.3 Checker (Reviewer) #
Purpose: Review and approve the analyst’s results to ensure accuracy and consistency.
Key permissions:
- Review all analyst-completed cases.
- Validate ACMG classifications and supporting evidence.
- Approve or reject reports for finalization.
- Add validation notes or revision requests.
Typical users:
Senior reviewers or quality assurance specialists ensuring scientific and procedural consistency.
3. Role Hierarchy and Permissions Summary #
| Role | Case Creation | ACMG Review | Report Approval | User Management | System Settings | API Access |
| Administrator | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Analyst | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ |
| Checker | ✓ | ✓ | ✓ | ✗ | ✗ | ✗ |
4. Flexibility and Customization #
SeqSMART’s role management system is fully customizable.
While the standard configuration suits most labs, institutions can redefine every part of it to fit their workflow, organizational structure, and internal compliance requirements.
Custom Role Management #
Client owners or authorized administrators can:
- Add new user roles with unique permissions.
- Modify or delete existing roles.
- Redefine access levels for each module (case management, ACMG classification, reporting, etc.).
- Save and apply custom role templates across the institution.
All configurations are managed through the Settings → Role Management section of the platform.
Workflow Customization #
Beyond user roles, SeqSMART allows clients to modify their case analysis workflow:
- Add new steps to the workflow (e.g., additional review layers or internal QC).
- Rename or reorder existing stages.
- Disable workflow steps that are not required in a given laboratory environment.
- Define transition permissions (who can move a case from one step to the next).
This adaptability ensures SeqSMART aligns perfectly with diverse institutional procedures — from small diagnostic labs to large-scale research infrastructures.
Expert Assistance #
For users who prefer support in customizing their environment, SeqSMART’s expert support team is available to help.
Clients can simply describe their preferred structure, and our specialists will configure it for them — ensuring proper integration and compliance with platform logic.
5. Security and Traceability #
All user actions — including role creation, permission changes, and workflow edits — are recorded in SeqSMART’s audit log.
This guarantees full traceability and compliance with institutional and regulatory standards.
Audit records include:
- Username and assigned role
- Timestamp and action type
- Case or module affected
- IP address and session identifier
Such transparency ensures both operational accountability and long-term data governance.
SeqSMART provides a secure and modular framework for managing user roles and access privileges.
Its standard role model supports efficient collaboration and review, while its flexibility empowers laboratories to reshape roles and workflow steps to match their own operational logic.
SeqSMART Role Model:
Structured by design — flexible by choice.